@prefix rdfs:    <http://www.w3.org/2000/01/rdf-schema#> .
@prefix foaf:    <http://xmlns.com/foaf/0.1/> .

_:b1  <http://www.w3.org/1999/02/22-rdf-syntax-ns#type>
              <http://purl.org/net/provenance/ns#Actor> , <http://purl.org/net/provenance/ns#DataProvidingService> , <http://purl.org/net/provenance/types#DataCreatingService> ;
      rdfs:seeAlso <https://research.tib.eu/covid-19/> ;
      <http://purl.org/net/provenance/ns#deployedSoftware>
              _:b2 .

<https://research.tib.eu/covid-19/entity/C0795657_PDQ>
      <http://www.w3.org/1999/02/22-rdf-syntax-ns#type>
              <https://research.tib.eu/covid-19/vocab/AnnotationDefinition> ;
      <http://www.w3.org/ns/prov#hasGeneratedBy>
              <https://research.tib.eu/covid-19/SourceName/PDQ> ;
      <https://research.tib.eu/covid-19/vocab/definition>
              "Human serum-derived alpha-1 proteinase inhibitor (alpha-1-antitrypsin or AAT) with immunomodulating and anti-inflammatory activity. Upon administration, AAT reduces the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, IL-32, IL-6, and proteinase 3, and induces the production of anti-inflammatory cytokines, such as IL-10 and the IL-1 receptor antagonist IL-1RN. This agent also downregulates heparan sulfate and reduces the expansion of cytotoxic effector T cells, interferes with the maturation of dendritic cells and increases T regulatory cells. Altogether, AAT may attenuate acute graft-versus-host disease (GvHD) and may facilitate graft acceptance and survival. In addition, AAT enhances levels of cAMP and activation of cAMP-dependent protein kinase A. AAT, a 52kD protein and serine protease inhibitor, belongs to the serpin superfamily. Check for \\'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82258\\' active clinical trials using this agent. (\\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C82258\\' NCI Thesaurus)" ;
      <https://research.tib.eu/covid-19/vocab/hasCUIAnnotation>
              <https://research.tib.eu/covid-19/entity/C0795657> .

<https://research.tib.eu/covid-19/data/entity/C0795657_PDQ?output=ttl>
      rdfs:label "RDF description of C0795657_PDQ" ;
      foaf:primaryTopic <https://research.tib.eu/covid-19/entity/C0795657_PDQ> .

[]    <http://www.w3.org/1999/02/22-rdf-syntax-ns#type>
              <http://usefulinc.com/ns/doap#Project> ;
      <http://usefulinc.com/ns/doap#homepage>
              <http://www4.wiwiss.fu-berlin.de/pubby/> ;
      <http://usefulinc.com/ns/doap#release>
              _:b2 .

[]    <http://rdfs.org/ns/void#sparqlEndpoint>
              <https://labs.tib.eu/sdm/covid19kg/sparql> .

_:b2  <http://www.w3.org/1999/02/22-rdf-syntax-ns#type>
              <http://usefulinc.com/ns/doap#Version> ;
      <http://usefulinc.com/ns/doap#revision>
              "0.4" .

<https://labs.tib.eu/sdm/covid19kg/sparql>
      <http://www.w3.org/1999/02/22-rdf-syntax-ns#type>
              <http://purl.org/net/provenance/ns#Actor> , <http://purl.org/net/provenance/types#DataCreatingService> .

_:b3  <http://www.w3.org/1999/02/22-rdf-syntax-ns#type>
              <http://purl.org/net/provenance/types#QueryResult> , <http://purl.org/net/provenance/ns#DataItem> , <http://www.w3.org/2004/03/trix/rdfg-1/Graph> ;
      <http://purl.org/net/provenance/ns#createdBy>
              _:b4 ;
      <http://purl.org/net/provenance/ns#retrievedBy>
              _:b5 .

_:b6  <http://www.w3.org/1999/02/22-rdf-syntax-ns#type>
              <http://purl.org/net/provenance/ns#DataCreation> ;
      <http://purl.org/net/provenance/ns#performedAt>
              "2026-05-18T00:02:40.551Z"^^<http://www.w3.org/2001/XMLSchema#dateTime> ;
      <http://purl.org/net/provenance/ns#performedBy>
              _:b1 ;
      <http://purl.org/net/provenance/ns#usedData>
              _:b3 .

_:b7  <http://www.w3.org/1999/02/22-rdf-syntax-ns#type>
              <http://purl.org/net/provenance/ns#DataItem> , <http://www.w3.org/2004/03/trix/rdfg-1/Graph> ;
      <http://purl.org/net/provenance/ns#createdBy>
              _:b6 ;
      <http://www.ontologydesignpatterns.org/cp/owl/informationrealization.owl#realizes>
              <https://research.tib.eu/covid-19/data/entity/C0795657_PDQ> ;
      foaf:primaryTopic <https://research.tib.eu/covid-19/entity/C0795657_PDQ> ;
      foaf:topic _:b7 .

_:b8  <http://www.w3.org/1999/02/22-rdf-syntax-ns#type>
              <http://purl.org/net/provenance/types#SPARQLQuery> , <http://spinrdf.org/sp#Describe> ;
      rdfs:label "DESCRIBE <http://research.tib.eu/covid-19/entity/C0795657_PDQ>"^^<http://www.w3.org/2001/XMLSchema#string> .

_:b5  <http://www.w3.org/1999/02/22-rdf-syntax-ns#type>
              <http://purl.org/net/provenance/ns#DataAccess> ;
      <http://purl.org/net/provenance/ns#accessedService>
              <https://labs.tib.eu/sdm/covid19kg/sparql> ;
      <http://purl.org/net/provenance/ns#performedAt>
              "2026-05-18T00:02:40.551Z"^^<http://www.w3.org/2001/XMLSchema#dateTime> ;
      <http://purl.org/net/provenance/ns#performedBy>
              _:b1 .

_:b4  <http://www.w3.org/1999/02/22-rdf-syntax-ns#type>
              <http://purl.org/net/provenance/ns#DataCreation> , <http://purl.org/net/provenance/types#QueryExecution> ;
      <http://purl.org/net/provenance/ns#performedBy>
              <https://labs.tib.eu/sdm/covid19kg/sparql> ;
      <http://purl.org/net/provenance/ns#usedGuideline>
              _:b8 .