PropertyValue
?:abstract
  • The coronavirus disease of 2019 (COVID-19) has caused an unprecedented global crisis. The etiological agent is a new virus called the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). As of October, 2020 there have been 45.4 million confirmed cases with a mortality rate of 2.6% globally. With the lack of a vaccine and effective treatments, the race is on to find a cure for the virus infection using specific antivirals. The viral RNA-dependent RNA polymerase, proteases, spike protein-host angiotensin-converting enzyme 2 binding and fusion have presented as attractive targets for pan-coronavirus and broad spectrum direct-acting antivirals (DAAs). This review presents a perspective on current re-purposing treatments and future DAAs.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.3389/fmicb.2020.587944
?:journal
  • Front_Microbiol
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/7b06cb9894f5c1c0b054a6bee93645eba9dfba74.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7688518.xml.json
?:pmcid
?:pmid
?:pmid
  • 33262747.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Current and Future Direct-Acting Antivirals Against COVID-19
?:type
?:year
  • 2020-11-12

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