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SESSION TITLE: Late-breaking Abstract Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: To examine COVID-19 patients requiring invasive mechanical ventilation (MV) and/or Extracorporeal Membrane Oxygenation (ECMO) to better understand patient selection for ECMO, clinical management, and short-term outcomes METHODS: Retrospective study of patients >18-years-old admitted to the hospital with COVID-19 requiring MV Lung-protective ventilation was used in all patients with initial set PEEP of 8-10 cm H20 for plateau pressure 65 years, multi-system organ failure, and MV >10 d Data captured included baseline patient characteristics, co-morbidities, pre-ECMO respiratory support, ECMO settings, laboratory results, and COVID-19 therapeutic interventions RESULTS: We analyzed 59 patients who required invasive MV, including 13 who met criteria for ECMO There were no between-group differences in gender, BMI, or co-morbidities More ECMO patients received Tocilizumab (p= 003), but steroid use was similar (p= 44) Nine ECMO (69 2%) patients were decannulated Crude ICU mortality was comparable between the ECMO and MV groups (6/13 [46 15%] vs 22/46 patients [47 82%];p=0 92) Higher pre-ECMO D-dimer (9 740 [4 84-20 00] mcg/mL vs 3 800 [2 19-9 11] mcg/mL;p=0 05), LDH (1158 ±344 5 units/L vs 575 9 ±124 0 units/L;p=0 001), and troponin (0 4315 ±0 465 ng/mL vs 0 034 ±0 043 ng/mL;p=0 04) were associated with mortality Time on MV was significantly longer in the ECMO group (563 3 [422 1-613 9] h vs 247 9 [101 8-479] h in MV;p< 001) as well as ICU length of stay (LOS) (576 2 [457 5-652 8] h in ECMO vs 322 2 [120 6-569 3] h in MV;p=0 01) CONCLUSIONS: ECMO was associated with prolonged MV and extended ICU LOS Markers of coagulation, inflammation and cardiac injury were elevated in ECMO patients who did not survive CLINICAL IMPLICATIONS: ECMO is a potentially effective rescue therapy for COVID-19 associated pneumonia DISCLOSURES: No relevant relationships by Muhtadi Alnababteh, source=Web Response No relevant relationships by Rajus Chopra, source=Web Response Speaker/Speaker\'s Bureau relationship with Boehringer Ingelheim Please note: $5001 - $20000 Added 07/01/2020 by Gail Drescher, source=Web Response, value=Consulting fee Technical Editor Resp Care Journal relationship with American Association for Respiratory Care Please note: $1001 - $5000 Added 07/01/2020 by Gail Drescher, source=Web Response, value=Salary No relevant relationships by Muhammad Hashmi, source=Web Response No relevant relationships by Fatima Hayat, source=Web Response No relevant relationships by Akshay Kohli, source=Web Response No relevant relationships by Emil Oweis, source=Web Response No relevant relationships by Karthik Vedantam, source=Web Response No relevant relationships by Akram Zaaqoq, source=Web Response
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