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?:abstract
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Background: Coronavirus disease 2019 (COVID-19) has already became a public health emergency of international concern COVID-19 related cardiac injury remains largely unclear Methods: We retrospectively analyzed demographic, clinical, laboratory and cardiovascular imaging data of all consecutively admitted adult COVID-19 patients in Zhuhai, China from January 17th, 2020 to February 18th, 2020 Results: A total of 93 patients were included in the study Acute cardiac injury was found in 9 (9 7%) COVID-19 patients with median level of hypersensitive cardiac troponin I (hs-cTnI) to be 0 085 μg/L (IQR 0 027–0 560 μg/L) Compared with patients without cardiac injury, the median age of patients with cardiac injury was significantly older (65 0 vs 44 0, P<0 05), hypertension was significantly more common (44 4% vs 14 3%, P<0 05), and the proportion of severe-critical cases were greater (77 8% vs 17 9%, P<0 05) Patients with cardiac injury were more likely have elevation of N-terminal proBNP (NT-proBNP) in comparison (66 7% vs 10 0%, P<0 05) There was no significant difference in echocardiographic parameters between patients with and without cardiac injury Multivariable logistic regression analysis indicated that older age (OR: 1 093, 95% CI: 1 011–1 182) and increased NT-proBNP (OR: 10 979, 95% CI: 2 024–59 555) were independent risk factors for cardiac injury Cardiac magnetic resonance (CMR) imaging performed on three patients at around one month after they underwent significant hs-cTnI elevation showed that they had underlying cardiovascular comorbidities Conclusions: Acute cardiac injury was seen in the minority of hospitalized COVID-19 patients in Zhuhai, China Older age and increased NT-proBNP were associated with acute cardiac injury © Cardiovascular Diagnosis and Therapy All rights reserved
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