| Property | Value |
|---|
|
?:abstract
|
-
Introduction The COVID-19 pandemic revealed the vulnerability of the general population to this infectious disease, which is determined by the lack of immunity to the new SARS-CoV-2 coronavirus and is characterized by cytokine storm in severe cases One of the most important reasons for this vulnerability is a high occurrence rate of micronutrient deficiencies, and above all, vitamin D deficiency Aim To systematize the available data on the role of vitamin D in the prevention of COVID-19 infection Materials and methods Systematic computer analysis of the entire array of available scientific publications on coronaviruses (21,300 publications in PUBMED and preprint repositories, including 7,500 publications on COVID-19 and SARS-CoV-2) was performed The methods of topological and metric data analysis were used About 50 most informative sections were identified that were mainly associated with COVID-19 / SARS-CoV-2 The analysis of the obtained “map” of molecular pathophysiology of COVID-19 was performed Results Vitamin D activates the expression of many genes involved in supporting the immunity against coronaviruses and other single-stranded RNA viruses (interferon-dependent protection) The results of the systematic analysis of the publications on coronavirus showed that vitamin D is important for attenuating the effects of the cytokine storm and compensating for chronic comorbid pathologies Conclusion The compensation for vitamin D deficiency is an essential component of COVID-19 prevention This tactics of prevention is less costly than managing patients with severe forms of COVID-19 and can help save public healthcare resources © 2020 IRBIS LLC All rights reserved
|
|
is
?:annotates
of
|
|
|
?:creator
|
|
|
?:journal
|
|
|
?:license
|
|
|
?:publication_isRelatedTo_Disease
|
|
|
is
?:relation_isRelatedTo_publication
of
|
|
|
?:source
|
|
|
?:title
|
-
COVID-19 pandemic: Protective role of vitamin D
|
|
?:type
|
|
|
?:who_covidence_id
|
|
|
?:year
|
|
![[This page as RDF]](https://research.tib.eu/covid-19/static/rdf-icon.gif){kind=icon}