PropertyValue
?:abstract
  • A recent genetic association study1 identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)2 comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe.
?:creator
?:journal
  • Nature
?:license
  • unk
?:publication_isRelatedTo_Disease
?:source
  • WHO
?:title
  • The major genetic risk factor for severe COVID-19 is inherited from Neanderthals
?:type
?:who_covidence_id
  • #808357
?:year
  • 2020

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