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Introduction: Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen Guidelines recommend controlled oxygen, for most patients with a recommended interval of SpO2 between 92 and 96% We aimed to determine if closed-loop control of oxygen was feasible in patients with COVID-19 and could maintain SpO2 in the specified interval Methods: Patients were prospectively enrolled in an observational study on a medical ward dedicated to patients with COVID-19 Closed-loop controlled oxygen was delivered by O2matic® which can deliver 0–15 liters/min and adjusts flow every second based on 15 seconds averaging of SpO2 measured by pulse oximetry Lung function parameters were measured at admission Results: Fifteen patients (six women, nine men) participated in the study Average age was 72 years Lung function was severely impaired with FEV1, FVC and PEF reduced to approximately 50% The average stay on the ward was 3 2 days and O2matic was used on average for 66 hours, providing 987 hours of observation O2matic maintained SpO2 in the desired interval for 82 9% of the time Time with SpO2 > 2% below interval was 5 1% and time with SpO2 > 2% above interval was 0 6% Conclusion: Closed-loop control of oxygen to patients with COVID-19 is feasible and can maintain SpO2 in the specified interval in the majority of time Closed-loop automated control could be of particular benefit for patients in isolation with decreased visibility, surveillance and monitoring Further studies must examine the clinical benefits
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European_Clinical_Respiratory_Journal
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Automatic oxygen titration with O2matic® to patients admitted with COVID-19 and hypoxemic respiratory failure
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