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?:abstract
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Introduction: To evaluate the recovery rate of loss of smell (LOS) with objective olfactory testing in COVID-19 patients Methods: Adults with confirmed COVID-19 and self-reported sudden LOS were prospectively recruited through a public call from the University of Mons (Belgium) Epidemiological and clinical data were collected using online patient-reported outcome questionnaires Patients benefited from objective olfactory evaluation (Sniffin-Sticks-test) and were invited to attend for repeated evaluation until scores returned to normal levels Results: From March 22 to May 22, 2020, 88 patients with sudden-onset LOS completed the evaluations LOS developed after general symptoms in 44 6% of cases Regarding objective evaluation, 22 patients (25 0%) recovered olfaction within 14 days following the onset of LOS The smell function recovered between the 16th and the 70th day post-LOS in 48 patients (54 5%) At the time of final assessment at 2 months, 20 5% of patients (N = 18) had not achieved normal levels of olfactory function Higher baseline severity of olfactory loss measured using Sniffin-Sticks was strongly predictive of persistent loss (p < 0 001) Conclusion: In the first 2 months, 79 5% of patients may expect to have complete recovery of their olfactory function The severity of olfactory loss, as detected at the first Sniffin-Sticks-test, may predict the lack of mid-term recovery
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