PropertyValue
?:abstract
  • In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.
is ?:annotates of
?:creator
?:doi
  • 10.3389/fimmu.2020.603428
?:doi
?:journal
  • Front_Immunol
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/a6525c736470b9d5431b126d0b152ca5129d1739.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7732473.xml.json
?:pmcid
?:pmid
?:pmid
  • 33329599.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report
?:type
?:year
  • 2020-11-24

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