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The uneven morphology and the trapped charges at the surface of the traditionally used supporting substrate-based 2D biosensors produces a scattering phenomenon, which leads to irregular signal from individually fabricated device. Though suspended 2D channel material has the potential to overcome scattering effects from the substrates but achieving reliability and selectivity, have been limiting the biosensor technology. Here, we have demonstrated nanogap electrodes fabrication by using the self-assembly technique, which provides suspension to the 2D-MoS(2). These nano-spacing electrodes not only give suspension but also provide robust strength to the atomic layer, which remains freestanding after coating of the Hafnium oxide (HfO(2)) as well as linkers and antibodies. For evaluating the electrical characteristics of suspended MoS(2) FET, gating potential was applied through electrolyte on suspended MoS(2) transistor, which achieved lower subthreshold swing 70 mV/dec and ON/OFF ratio 10(7). Afterward, pH detection has demonstrated at room temperature, which shows an impressive sensitivity of ∼880 by changing 1 unit of pH. Besides, we have successfully shown Escherichia coli (E. coli) bacteria sensing from suspended MoS(2) transistor by functionalizing dielectric layer with E. coli antibodies. The reported biosensor has shown the ∼9% of conductance changes with a lower concentration of E. coli (10 CFU/mL; colony-forming unit per mL) as well as maintain the constant sensitivity in three fabricated devices. This type of the architecture has a potential to detect range of biomolecules such as COVID-19 viruses also by altering the oxide surface.
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?:doi
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10.1016/j.bios.2020.112724
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document_parses/pdf_json/375438c19a4857d1929cc9e6a953bb7b70800f03.json
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document_parses/pmc_json/PMC7568125.xml.json
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Reliable and highly sensitive biosensor from suspended MoS(2) atomic layer on nano-gap electrodes
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