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SESSION TITLE: Critical Care Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: October 18-21, 2020 PURPOSE: SARs-CoV-2 (COVID-19), was declared a global pandemic by the World Health Organization on March 11, 2020 Hence, there is an urgency to find effective treatment Data are needed regarding the benefit of treatment and prevention of the cytokine storms in COVID-19 patients with Tocilizumab METHODS: Clinical outcomes data for patients admitted to Orange Regional Medical Center with confirmed COVID-19 from Mar 15, 2020 to Apr 20, 2020 were identified through electronic health record chart review We conducted a retrospective case-control study in confirmed COVID 19 positive patients with ARDS requiring mechanical ventilation and compared outcome in terms of mortality and length of stay amongst those who received Tocilizumab as treatment modality opposed to those that did not RESULTS: A total of 94 patients with COVID-19 ARDS were analyzed 44 were in the study group and 50 in the control group We tried to match both group as close as possible in terms of age, sex, BMI and HS score- calculated using inflammatory markers- ferritin, triglycerides, AST and fibrinogen The median age was 55 5 years in the study group and 66 in the control group, difference was not statistically significant Average HS score was 114 in the Tocilizumab group and 92 in the control group, difference was statistically significant with P<0 0001 Also, the patients in the study group had elevated levels of IL-6, triglycerides, AST, ferritin which were statistically significant with p < 0 0001 when compared to the control group Length of stay was longer, average 17 9 days in the Tocilizumab Survival rate was much lower at 48 % in the control group and 61 36 % in patients who received Tocilizumab with significant P value of < 0 00001 The number needed to treat (NNT) was 7 48, if we treat 8 patients with Tocilizumab, 1 will not die CONCLUSIONS: Cytokine Release Syndrome (CRS) occurs in a large number of patients with severe COVID-19, which is also an important cause of death IL- 6 is the key molecule of CRS, so IL-6R antagonist Tocilizumab may be of value in improving outcomes In our study Tocilizumab group seemed to have improved survival outcome Results have to be interpreted with caution since this is a retrospective study and mortality is affected by multiple, confounding factors We await the results of ongoing randomized controlled trials to definitely answer the question of whether Tocilizumab improves survival in COVID-19 ARDS patients CLINICAL IMPLICATIONS: There are over 5 8 million confirmed cases and 360,412 deaths have been identified worldwide as of May 28, 2020 due to SARs-CoV-2 (COVID-19) Our study showed improved survival outcome in COVID-19 ARDS patients treated with Tocilizumab DISCLOSURES: No relevant relationships by Naim Ahmed, source=Web Response No relevant relationships by Samer El Zarif, source=Web Response No relevant relationships by Jodi Galaydick, source=Web Response No relevant relationships by JULIA GALEA, source=Web Response No relevant relationships by Aamir Gilani, source=Web Response No relevant relationships by Maida Khan, source=Web Response No relevant relationships by Shravan Kooragayalu, source=Web Response No relevant relationships by Murali Krishna, source=Web Response No relevant relationships by Karthika Linga, source=Web Response No relevant relationships by Maria Osundele, source=Web Response No relevant relationships by Mannu Shergill, source=Web Response No relevant relationships by Lauren Stuczynski, source=Web Response No relevant relationships by Nafisa Wadud, source=Web Response
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