PropertyValue
?:abstract
  • The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused coronavirus disease-2019 (COVID-19) pandemic Despite the intensive research currently, there are no therapeutics and vaccines available As the main protease (MsupPro/sup) plays a vital role in SARS-CoV-2, it is an attractive drug target Herein we report, potential inhibitors form natural products and synthetic drugs against MsupPro/sup In detail, we studied the interaction of inhibitors (Curcumin, Theaflavin, Deserpidine, Betulinic acid, Sinigrin, Emodin, Leptodactylone, Synthetic drugs, Lopinavir, Ritonavir, Indinavir, Amprenavir, Darunavir, Nelfinavir, Remdesivir, Saquinavir, Sivelestat, Galidesivir, and Favipiravir) with the catalytic site of MsupPro/sup Lastly, ADME (Absorption, Distribution, Metabolism, and Excretion) properties of Natural products and synthetic drugs are explored We identified eight potential inhibitors against MsupPro/sup b/b
is ?:annotates of
?:creator
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • Genetic Algorithm-Based Docking of Potent Inhibitors Against SARS-CoV-2 Main Protease: A Comparison Between Natural Products and Synthetic Drugs
?:type
?:who_covidence_id
  • #305
?:year
  • 2020

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