PropertyValue
?:abstract
  • BACKGROUND: The highly pathogenic avian influenza (HPAI) H5N1 virus poses a potential threat to the poultry industry. The currently available avian influenza H5N1 vaccines for poultry are clade-specific. Therefore, an effective vaccine for preventing and controlling H5N1 viruses belonging to different clades needs to be developed. RESULTS: Recombinant L. lactis/pNZ8148-Spax-HA was generated, and the influenza virus haemagglutinin (HA) protein of A/Vietnam/1203/2004 (H5N1) was displayed on the surface of Lactococcus lactis (L. lactis). Spax was used as an anchor protein. Chickens vaccinated orally with unadjuvanted L. lactis/pNZ8148-Spax-HA could produce significant humoral and mucosal responses and neutralizing activities against H5N1 viruses belonging to different clades. Importantly, unadjuvanted L. lactis/pNZ8148-Spax-HA conferred cross-clade protection against lethal challenge with different H5N1 viruses in the chicken model. CONCLUSION: This study provides insights into the cross-clade protection conferred by unadjuvanted L. lactis/pNZ8148-Spax-HA, and the results might help the establishment of a promising platform for the development of a safe and effective H5N1 cross-clade vaccine for poultry.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1186/s12934-020-01453-7
?:externalLink
?:journal
  • Microb_Cell_Fact
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/21743aa14476093916815a1a4c95e939ce7ad834.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7557258.xml.json
?:pmcid
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • PMC
?:title
  • Haemagglutinin displayed on the surface of Lactococcus lactis confers broad cross-clade protection against different H5N1 viruses in chickens
?:type
?:year
  • 2020-10-15

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