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Case reports of patients with coronavirus disease-2019 (COVID-19) who have been discharged and subsequently report positive reverse transcription-polymerase chain reaction again (hereafter referred as \'re-positive\') do not fully describe the magnitude and significance of this issue To determine the re-positive rate (proportion) and review probable causes and outcomes, we conduct a retrospective study of all 119 discharged patients in Brunei Darussalam up till April 23 Patients who were discharged are required to self-isolate at home for 14 days and undergo nasopharyngeal specimen collection postdischarge Discharged patients found to be re-positive were readmitted We reviewed the clinical and epidemiological records of all discharged patients and apply log-binomial models to obtain risk ratios for re-positive status One in five recovered patients subsequently test positive again for severe acute respiratory syndrome coronavirus 2-this risk is more than six times higher in persons aged 60 years and above The average Ct value of re-positive patients was lower predischarge compared with their readmission Ct value Out of 111 close contacts tested, none were found to be positive as a result of exposure to a re-positive patient Our findings support prolonged but intermittent viral shedding as the probable cause for this phenomenon We did not observe infectivity potential in these patients
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Journal_of_Medical_Virology
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Probable causes and risk factors for positive SARS-CoV-2 test in recovered patients: evidence from Brunei Darussalam. (Special issue on new coronavirus (2019-nCoV or SARS-CoV-2) and the outbreak of the respiratory illness (COVID-19): part-VII.)
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