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Immune homeostasis is the state where the immune system maintains stability in the absence of insult Much of the analysis of immune homeostasis has focused on systemic immunity, but it is also likely to be important in an organ specific manner There is evidence that homeostatic immunity can affect subsequent responses to infection or vaccination Since the lungs are a major site of infection, we used the Collaborative Cross (CC) mouse genetic reference population to study the genetic regulation of the breadth of baseline immune cell populations in the lung and identify loci regulating these cells at the steady state We found that all immune cell populations measured showed strong genetic (i e strain-specific) variation in cell type abundances We identified 12 quantitative trait loci (QTL) associated with variation in 12 immune cell populations or the relationships between cell populations Given the role of various immune cells in the lungs during respiratory virus pathogenesis, we asked whether any of the mapped QTL correlated with influenza A virus (IAV) or Severe acute respiratory syndrome associated coronavirus (SARS-CoV) disease following infection in the same strains of mice Notably, a locus we mapped for baseline abundance of CD8+ T cells in the lungs was associated with peak weight loss following IAV infection Additionally, a locus mapped for variation in Ly6C+ monocyte/macrophage abundance was associated with SARS-CoV titer at days 2 and 4 post-infection These data suggest that abundance of lung leukocyte populations prior to infection could serve as predictors of immune responses to respiratory viruses
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Genetic regulation of immune homeostatic lung leukocyte populations
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