[\'Gilead Sciences, 333 Lakeside Dr, Foster City, CA, USA. Electronic address: ross.martin@gilead.com.\', \'Gilead Sciences, 333 Lakeside Dr, Foster City, CA, USA.\']
Genetic conservation of SARS-CoV-2 RNA replication complex in globally circulating isolates and recently emerged variants from humans and minks suggests minimal pre-existing resistance to remdesivir.