PropertyValue
?:abstract
  • During the COVID-19 pandemic, children have had markedly different clinical presentations and outcomes compared to adults In the acute phase of infection, younger children are relatively spared the severe consequences reported in adults Yet, they are uniquely susceptible to the newly described Multisystem Inflammatory Syndrome in Children (MIS-C) This may result from the developmental \'immunodeficiency\' resulting from a Th2 polarization that starts in utero and is maintained for most of the first decade of life MIS-C may be due to IgA complexes in a Th2 environment or a Th1-like response to COVID-19 antigens that developed slowly Alternatively, MIS-C may occur in vulnerable hosts with genetic susceptibilities in other immune and non-immune pathways Herein, we present a brief overview of the host immune response, virologic and genetic factors, and comparable inflammatory syndromes that may explain the pathophysiology leading to drastic differences in clinical presentation and outcomes of COVID-19 between children and adults
is ?:annotates of
?:creator
?:journal
  • Front_Pediatr
?:license
  • unk
?:publication_isRelatedTo_Disease
is ?:relation_isRelatedTo_publication of
?:source
  • WHO
?:title
  • COVID-19 in Children: A Review and Parallels to Other Hyperinflammatory Syndromes
?:type
?:who_covidence_id
  • #983736
?:year
  • 2020

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