PropertyValue
?:abstract
  • The UK\'s COVID-19 epidemic during early 2020 was one of world\'s largest and unusually well represented by virus genomic sampling. Here we reveal the fine-scale genetic lineage structure of this epidemic through analysis of 50,887 SARS-CoV-2 genomes, including 26,181 from the UK sampled throughout the country\'s first wave of infection. Using large-scale phylogenetic analyses, combined with epidemiological and travel data, we quantify the size, spatio-temporal origins and persistence of genetically-distinct UK transmission lineages. Rapid fluctuations in virus importation rates resulted in >1000 lineages; those introduced prior to national lockdown were larger and more dispersed. Lineage importation and regional lineage diversity declined after lockdown, whilst lineage elimination was size-dependent. We discuss the implications of our genetic perspective on transmission dynamics for COVID-19 epidemiology and control.
is ?:annotates of
?:creator
?:doi
?:doi
  • 10.1101/2020.10.23.20218446
?:license
  • medrxiv
?:pdf_json_files
  • document_parses/pdf_json/7631f3ab54564b70923c7d1a15a4da13ef89a22a.json
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • MedRxiv; WHO
?:title
  • Establishment & lineage dynamics of the SARS-CoV-2 epidemic in the UK
?:type
?:year
  • 2020-10-27

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