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Severe coronavirus disease 2019 (COVID-19) causes a hyperactivation of immune cells, resulting in lung inflammation. Recent studies showed that COVID-19 induces the production of factors previously implicated in the reawakening of dormant breast cancer cells such as neutrophil extracellular traps (NETs). The presence of NETs and of a pro-inflammatory microenvironment may therefore promote breast cancer reactivation, increasing the risk of pulmonary metastasis. Further studies will be required to confirm the link between COVID-19 and cancer recurrence. However, an increased awareness on the potential risks for breast cancer patients with COVID-19 may lead to improved treatment strategies to prevent metastatic relapse.
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10.1186/s13058-020-01360-0
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document_parses/pdf_json/01bbb4301fc0976a3a4d8fa602a1f686863568ef.json
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document_parses/pmc_json/PMC7598231.xml.json
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COVID-19: a potential driver of immune-mediated breast cancer recurrence?
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