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To Respected Sir/Madam Chemarxiv /Respected Sir/Madam /Su: submission of preprint of article to Chemarxiv for online publication am herewith submitting the preprint of an article entitled “Molecular docking studies of N-acetyl cysteine, zinc acetyl cysteine and niclosamide on SARS Cov 2 protease and its comparison with hydroxychloroquine†for possible publication in “Chemarxiv†/In this article, we have evaluated the binding abilities of N-acetyl cysteine, zinc acetyl cysteine and niclosamide (antiviral drug) with SARS-COV-2 protease All the four compounds investigated are effective and selectively bind to active sites of main protease N-acetyl cysteine being a derivative of cysteine interacts with Cys-145, His-163, Gly-143 of COV-2 protease, zinc acetyl cysteine binds to Gly-143, Ser-144, Cys-145, Glu-166 of COV-2 protease and niclosamide bind to Glu-166, Cys-145, His 41 of main protease The data has been compared with hydroxychloroquine which effectively binds to Cys-145, Glu-166, Arg-188 The binding affinities of N-acetyl cysteine, zinc-acetyl cysteine and niclosamide are -4 24, -4 29 and -7 5 kcal mol su-1 /suwhile for hydroxychloroquine it is -6 66 kcal mol su-1 /su Niclosamide with its lowest binding energy interacts with His-41 and Cys-145 which may be the first molecule to show such binding interaction The results indicate that N-acetyl cysteine, zinc-acetyl cysteine and niclosamide can also be explored for the treatment for SARS COV-2 as an alternative for hydroxychloroquine hope that the manuscript will full fill the journal’s requirements and will get accepted for publication Thanking you /With regards Roopa Guthappa a href=\'mailto:roopag81@yahoo com\' roopag81@yahoo com /a
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