PropertyValue
?:abstract
  • The outbreak of the SARS-CoV-2 virus in December 2019 has caused the deaths of several hundred thousand people worldwide. Currently, the pathogenesis of COVID-19 is poorly understood. During the course of COVID-19 infection, many patients experience deterioration, which might be associated with systemic inflammation and cytokine storm syndrome; however, other patients have mild symptoms or are asymptomatic. There are some suggestions that impaired cellular immunity through a reduction in Th1 response and IFNG (interferon gamma) expression, as well as cross-reactivity with common cold coronaviruses, might be involved in the differential COVID-19 course. Here, we show that CD4+ cells isolated from unexposed healthy donors that were differentiated towards the Th1 lineage in the presence of SARS-CoV-2 proteins exhibited induction of IFNG. Interestingly, the same cells induced to differentiate towards a Th17 lineage did not exhibit changes in IFNG expression or Th17-related cytokines. This suggests the cellular response to SARS-CoV-2 viral proteins is primarily associated with Th1 lymphocytes and may be dependent on past infections with common cold coronaviruses or vaccinations that induce unspecific cellular responses, e.g., BCG (Bacillus Calmette-GuĂ©rin). Thus, our results might explain the high variability in the course of COVID-19 among populations of different countries.
is ?:annotates of
?:creator
?:doi
  • 10.3390/vaccines8040673
?:doi
?:journal
  • Vaccines_(Basel)
?:license
  • cc-by
?:pdf_json_files
  • document_parses/pdf_json/2334f914330a17b36c9661b81ade8753236dc53b.json
?:pmc_json_files
  • document_parses/pmc_json/PMC7712722.xml.json
?:pmcid
?:pmid
?:pmid
  • 33198287.0
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • Medline; PMC
?:title
  • SARS-CoV-2 Proteins Induce IFNG in Th1 Lymphocytes Generated from CD4+ Cells from Healthy, Unexposed Polish Donors
?:type
?:year
  • 2020-11-12

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