ftsozmo

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?:abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a global pandemic, and cases continue to rise Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months Our data further reveal that SARS-CoV-2specific IgG memory B cells increased over time Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a global pandemic, and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity. We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory. Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months. Our data further reveal that SARS-CoV-2-specific IgG memory B cells increased over time. Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies. Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.
is ?:annotates of	<https://research.tib.eu/covid-19/entity/6ftsozmo_hasAnnotation_C0042776> <https://research.tib.eu/covid-19/entity/6ftsozmo_hasAnnotation_C5203676>
?:creator	<https://research.tib.eu/covid-19/entity/Rodda%2C_L._B.%3B_Netland%2C_J.%3B_Shehata%2C_L.%3B_Pruner%2C_K._B.%3B_Morawski%2C_P._A.%3B_Thouvenel%2C_C._D.%3B_Takehara%2C_K._K.%3B_Eggenberger%2C_J.%3B_Hemann%2C_E._A.%3B_Waterman%2C_H._R.%3B_Fahning%2C_M._L.%3B_Chen%2C_Y.%3B_Hale%2C_M.%3B_Rathe%2C_J.%3B_Stokes%2C_C.%3B_Wrenn%2C_S.%3B_Fiala%2C_B.%3B_Carter%2C_L.%3B_Hamerman%2C_J._A.%3B_King%2C_N._P.%3B_Gale%2C_M.%3B_Campbell%2C_D._J.%3B_Rawlings%2C_D._J.%3B_Pepper%2C_M.> <https://research.tib.eu/covid-19/entity/Rodda%2C_Lauren_B%3B_Netland%2C_Jason%3B_Shehata%2C_Laila%3B_Pruner%2C_Kurt_B%3B_Morawski%2C_Peter_A%3B_Thouvenel%2C_Christopher_D%3B_Takehara%2C_Kennidy_K%3B_Eggenberger%2C_Julie%3B_Hemann%2C_Emily_A%3B_Waterman%2C_Hayley_R%3B_Fahning%2C_Mitchell_L%3B_Chen%2C_Yu%3B_Hale%2C_Malika%3B_Rathe%2C_Jennifer%3B_Stokes%2C_Caleb%3B_Wrenn%2C_Samuel%3B_Fiala%2C_Brooke%3B_Carter%2C_Lauren%3B_Hamerman%2C_Jessica_A%3B_King%2C_Neil_P%3B_Gale%2C_Michael%3B_Campbell%2C_Daniel_J%3B_Rawlings%2C_David_J%3B_Pepper%2C_Marion>
?:journal	Cell
?:license	unk
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
is ?:relation_isRelatedTo_publication of	<https://research.tib.eu/covid-19/entity/6ftsozmo_HAS_C0024264_PRODUCES_C0003250> <https://research.tib.eu/covid-19/entity/6ftsozmo_HAS_C0682638_PRODUCES_C0597357> <https://research.tib.eu/covid-19/entity/6ftsozmo_HAS_C0682639_PRODUCES_C0079189>
?:source	WHO
?:title	Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:who_covidence_id	#1064911 #938808
?:year	2020 2021

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Value

?:abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a global pandemic, and cases continue to rise Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months Our data further reveal that SARS-CoV-2specific IgG memory B cells increased over time Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a global pandemic, and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity. We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory. Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months. Our data further reveal that SARS-CoV-2-specific IgG memory B cells increased over time. Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies. Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.

is ?:annotates of