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Purpose Reported rates of acute kidney injury (AKI) have varied significantly among studies of coronavirus disease 2019 (COVID-19) published to date. The present meta-analysis was conducted to gain clarity regarding AKI incidence and renal replacement therapy (RRT) use in COVID-19 patients. Methods The PubMed, Embase, Web of Science, medRxiv, and bioRxiv databases were systematically searched for COVID-19-related case reports published through 25 July 2020. Pooled analyses were conducted using R. Results The pooled incidence of AKI in 51 studies including 21531 patients was 12.3% (95% CI 9.5%-15.6%), with higher rates of 38.9% in 290 transplant patients (95% CI 27.3%-51.9%), 39.0% in 565 ICU patients (95% CI 23.2%-57.6%) and 42.0% among 1745 deceased patients (95% CI 30.3%-54.7%). RRT usage was reported in 39 studies of 17664 patients, with an overall pooled use of 5.4% (95% CI 4.0%-7.1%), with higher rates of 15.6% in 117 transplant patients (95%CI 9.9%-23.8%) and 16.3% in 776 ICU patients (95% CI 11.1%-23.3%). Conclusion AKI and RRT use among COVID-19 patients represent a major public health concern, and early and appropriate intervention should be called upon to improve the prognosis of patients suffering from AKI.
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10.1016/j.intimp.2020.107159
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document_parses/pdf_json/2bd8738e37f2d7f0148fe5f4e22dd2bc5b60f926.json
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Acute kidney injury and renal replacement therapy in COVID-19 patients: a systematic review and meta-analysis
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