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?:abstract
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Background: Since its declaration in december 2019, a novel coronavirus, the SARS-CoV-2 was rapidly responsible for a major pandemic COVID-19 is mainly manifested by respiratory symptoms, however, digestive manifestations have been reported, raising the hypothesis of the viral digestive tropism Aims: Specify the digestive manifestations due to the SARS-CoV-2, and their impact on the disease prognosis and describe the COVID-19 effect in patients with an underlying digestive disease Methods: A general review of the medical literature was conducted via Medline® database, through various combinations of the following keywords: SARS-CoV-2, COVID-19, gastrointestinal tract, digestive system, inflammatory bowel diseases, liver, liver injury, chronic liver disease, neoplasms The most relevant articles were selected Results: The SARS-CoV-2 tropism for the digestive tract has been confirmed by the identification of the enterocyte as a target cell of the virus Viral particles and RNA detection in stool of infected patients has raised a potential feco-oral transmission of the virus Gastrointestinal manifestations were frequent and may even be revealing or isolated Diarrhea was the most characteristic symptom Frequent liver involvement is associated with a more severe form of the disease Patients with digestive cancers and chronic liver diseases are at risk for a severe form of SARS-CoV-2 infection Conclusion: The clinician is required to know this type of manifestations in order to limit the delay in diagnosis and to better assess the prognosis © 2020, Maison du Medicine All rights reserved
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