PropertyValue
?:abstract
  • A way to study the mutation pattern is to convert a 20-letter protein sequence into a scalar protein sequence, because the 20-letter protein sequence is neither vector nor scalar while a promising way to study patterns is in numerical domain. In this study, we use the amino-acid pair predictability to convert α-galactosidase A with its 137 mutations into scalar sequences, and analyse which amino-acid pairs are more sensitive to mutation. Our results show that the unpredictable amino-acid pairs are more sensitive to mutation, and the mutation trend is to narrow the difference between predicted and actual frequency of amino-acid pairs.
?:creator
?:doi
?:doi
  • 10.1007/s11030-009-9158-4
?:externalLink
?:journal
  • Mol_Divers
?:license
  • no-cc
?:pdf_json_files
  • document_parses/pdf_json/b1e02833bf7b2d8db0c1c82d9f5186392f14ae24.json
?:pmcid
?:pmid
?:pmid
  • 19468850
?:publication_isRelatedTo_Disease
?:sha_id
?:source
  • PMC
?:title
  • Mutation patterns in human α-galactosidase A
?:type
?:year
  • 2009-05-26

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