j1zku9w

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?:abstract	IMPORTANCE: Although plenty of data exist regarding clinical manifestations, course, case fatality rate, and risk factors associated with mortality in severe coronavirus disease 2019 (COVID-19), long-term respiratory and functional sequelae in survivors of COVID-19 are unknown. OBJECTIVE: To evaluate the prevalence of lung function anomalies, exercise function impairment, and psychological sequelae among patients hospitalized for COVID-19, 4 months after discharge. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study at an academic hospital in Northern Italy was conducted among a consecutive series of patients aged 18 years and older (or their caregivers) who had received a confirmed diagnosis of severe acute respiratory coronavirus 2 (SARS-CoV-2) infection severe enough to require hospital admission from March 1 to June 29, 2020. SARS-CoV-2 infection was confirmed via reverse transcription–polymerase chain reaction testing, bronchial swab, serological testing, or suggestive computed tomography results. EXPOSURE: Severe COVID-19 requiring hospitalization. MAIN OUTCOMES AND MEASURES: The primary outcome of the study was to describe the proportion of patients with a diffusing lung capacity for carbon monoxide (D(lco)) less than 80% of expected value. Secondary outcomes included proportion of patients with severe lung function impairment (defined as D(lco) <60% expected value); proportion of patients with posttraumatic stress symptoms (measured using the Impact of Event Scale–Revised total score); proportion of patients with functional impairment (assessed using the Short Physical Performance Battery [SPPB] score and 2-minute walking test); and identification of factors associated with D(lco) reduction and psychological or functional sequelae. RESULTS: Among 767 patients hospitalized for severe COVID-19, 494 (64.4%) refused to participate, and 35 (4.6%) died during follow-up. A total of 238 patients (31.0%) (median [interquartile range] age, 61 [50-71] years; 142 [59.7%] men; median [interquartile range] comorbidities, 2 [1-3]) consented to participate to the study. Of these, 219 patients were able to complete both pulmonary function tests and D(lco) measurement. D(lco) was reduced to less than 80% of the estimated value in 113 patients (51.6%) and less than 60% in 34 patients (15.5%). The SPPB score was suggested limited mobility (score <11) in 53 patients (22.3%). Patients with SPPB scores within reference range underwent a 2-minute walk test, which was outside reference ranges of expected performance for age and sex in 75 patients (40.5%); thus, a total of 128 patients (53.8%) had functional impairment. Posttraumatic stress symptoms were reported in a total of 41 patients (17.2%). CONCLUSIONS AND RELEVANCE: These findings suggest that at 4 months after discharge, respiratory, physical, and psychological sequelae were common among patients who had been hospitalized for COVID-19.
?:creator	<https://research.tib.eu/covid-19/entity/Bellan%2C_Mattia%3B_Soddu%2C_Daniele%3B_Balbo%2C_Piero_Emilio%3B_Baricich%2C_Alessio%3B_Zeppegno%2C_Patrizia%3B_Avanzi%2C_Gian_Carlo%3B_Baldon%2C_Giulia%3B_Bartolomei%2C_Giuseppe%3B_Battaglia%2C_Marco%3B_Battistini%2C_Sofia%3B_Binda%2C_Valeria%3B_Borg%2C_Margherita%3B_Cantaluppi%2C_Vincenzo%3B_Castello%2C_Luigi_Mario%3B_Clivati%2C_Elisa%3B_Cisari%2C_Carlo%3B_Costanzo%2C_Martina%3B_Croce%2C_Alessandro%3B_Cuneo%2C_Daria%3B_De_Benedittis%2C_Carla%3B_De_Vecchi%2C_Simona%3B_Feggi%2C_Alessandro%3B_Gai%2C_Martina%3B_Gambaro%2C_Eleonora%3B_Gattoni%2C_Eleonora%3B_Gramaglia%2C_Carla%3B_Grisafi%2C_Leonardo%3B_Guerriero%2C_Chiara%3B_Hayden%2C_Eyal%3B_Jona%2C_Amalia%3B_Invernizzi%2C_Marco%3B_Lorenzini%2C_Luca%3B_Loreti%2C_Lucia%3B_Martelli%2C_Maria%3B_Marzullo%2C_Paolo%3B_Matino%2C_Erica%3B_Panero%2C_Antonio%3B_Parachini%2C_Elena%3B_Patrucco%2C_Filippo%3B_Patti%2C_Giuseppe%3B_Pirovano%2C_Alice%3B_Prosperini%2C_Pierluigi%3B_Quaglino%2C_Riccardo%3B_Rigamonti%2C_Cristina%3B_Sainaghi%2C_Pier_Paolo%3B_Vecchi%2C_Camilla%3B_Zecca%2C_Erika%3B_Pirisi%2C_Mario>
?:doi	10.1001/jamanetworkopen.2020.36142
?:doi	<https://research.tib.eu/covid-19/entity/10.1001/jamanetworkopen.2020.36142>
?:journal	JAMA_Netw_Open
?:license	cc-by
?:pmc_json_files	document_parses/pmc_json/PMC7841464.xml.json
?:pmcid	<https://research.tib.eu/covid-19/entity/PMC7841464>
?:pmid	<https://research.tib.eu/covid-19/entity/33502487.0>
?:pmid	33502487.0
?:publication_isRelatedTo_Disease	<https://research.tib.eu/covid-19/entity/COVID-19>
?:source	Medline; PMC
?:title	Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge
?:type	<https://research.tib.eu/covid-19/vocab/Publication>
?:year	2021-01-27

Property

Value

?:abstract

IMPORTANCE: Although plenty of data exist regarding clinical manifestations, course, case fatality rate, and risk factors associated with mortality in severe coronavirus disease 2019 (COVID-19), long-term respiratory and functional sequelae in survivors of COVID-19 are unknown. OBJECTIVE: To evaluate the prevalence of lung function anomalies, exercise function impairment, and psychological sequelae among patients hospitalized for COVID-19, 4 months after discharge. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study at an academic hospital in Northern Italy was conducted among a consecutive series of patients aged 18 years and older (or their caregivers) who had received a confirmed diagnosis of severe acute respiratory coronavirus 2 (SARS-CoV-2) infection severe enough to require hospital admission from March 1 to June 29, 2020. SARS-CoV-2 infection was confirmed via reverse transcription–polymerase chain reaction testing, bronchial swab, serological testing, or suggestive computed tomography results. EXPOSURE: Severe COVID-19 requiring hospitalization. MAIN OUTCOMES AND MEASURES: The primary outcome of the study was to describe the proportion of patients with a diffusing lung capacity for carbon monoxide (D(lco)) less than 80% of expected value. Secondary outcomes included proportion of patients with severe lung function impairment (defined as D(lco) <60% expected value); proportion of patients with posttraumatic stress symptoms (measured using the Impact of Event Scale–Revised total score); proportion of patients with functional impairment (assessed using the Short Physical Performance Battery [SPPB] score and 2-minute walking test); and identification of factors associated with D(lco) reduction and psychological or functional sequelae. RESULTS: Among 767 patients hospitalized for severe COVID-19, 494 (64.4%) refused to participate, and 35 (4.6%) died during follow-up. A total of 238 patients (31.0%) (median [interquartile range] age, 61 [50-71] years; 142 [59.7%] men; median [interquartile range] comorbidities, 2 [1-3]) consented to participate to the study. Of these, 219 patients were able to complete both pulmonary function tests and D(lco) measurement. D(lco) was reduced to less than 80% of the estimated value in 113 patients (51.6%) and less than 60% in 34 patients (15.5%). The SPPB score was suggested limited mobility (score <11) in 53 patients (22.3%). Patients with SPPB scores within reference range underwent a 2-minute walk test, which was outside reference ranges of expected performance for age and sex in 75 patients (40.5%); thus, a total of 128 patients (53.8%) had functional impairment. Posttraumatic stress symptoms were reported in a total of 41 patients (17.2%). CONCLUSIONS AND RELEVANCE: These findings suggest that at 4 months after discharge, respiratory, physical, and psychological sequelae were common among patients who had been hospitalized for COVID-19.

?:creator