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BACKGROUND: Non-operational treatments for Morton\'s neuroma remain controversial because it was believed sclerosing injections do not change nerve fibers on a cellular level. Up to 80% success rates with 4% ethanol sclerosing have been documented while the remainder require operational removal of the painful nerve. We sought to evaluate the histological characteristics of Morton\'s neuromas treated with either 4% ethanol sclerosing injection versus steroid injection alone from patients who required removal of the nerve for pain relief. METHODS: A retrospective histologic review was performed on 24 consecutive patients who were treated with either sclerosing injection versus non-sclerosing injection and underwent nerve removal between 2012 to 2015. RESULTS: 19 patients met inclusion criteria, of which 8 patients received sclerosing injections and 11 patients received non-sclerosing injections. Intraneural fibrosis was seen higher in the non-sclerosing injection group (p = 0.008). CONCLUSIONS: Histological changes are seen in Morton\'s neuroma with the use of 4% ethanol sclerosing injection contrary to prior studies.
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J._Am._Podiatr._Med._Assoc
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?:title
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Effects of 4% Ethanol Sclerosing Injection on Morton\'s Neuroma: A histological study
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