?:abstract
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AFTER SARS-CoV-2 virus pandemic that started in 2019, it has been observed that the vast majority of people have a mild clinical picture or are completely asymptomatic However, around 15% of affected people will have a severe, potentially fatal clinical course associated with hyperinflammation, similar to the macrophage activation syndromes Individuals with mild clinical COVID-19 have an efficient innate immune response and an adaptive response that kills virus-infected cells leaving immune memory Severe symptoms occur in individuals with proinflammatory stages who have a late innate immune response, hyperinflammation and \'cytokine storm\' phenomenon induced by the innate immune system and associated with defects in adaptive immunity
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