PropertyValue
?:abstract
  • Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene-containing mono- and bisQACs were prepared in high yields and tested for activity against a panel of bacteria, including Gram-negative and resistant strains. Ferrocene QACs were shown to be effective antiseptics, with bisQAC Fe-11,11 displaying single-digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs.
is ?:annotates of
?:creator
?:doi
  • 10.1002/cmdc.202000605
?:doi
?:journal
  • ChemMedChem
?:license
  • unk
?:pmid
?:pmid
  • 33197298.0
?:publication_isRelatedTo_Disease
?:source
  • Medline
?:title
  • Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures.
?:type
?:year
  • 2020-11-16

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