Property | Value |
?:abstract
|
-
SARS-CoV-2 virus, a member of the Coronaviridae family, causes Covid-19 pandemic disease with severe respiratory illness. Multiple strategies enable SARS-CoV-2 to eventually overcome antiviral innate immune mechanisms which are important components of viral pathogenesis. This review considers several mechanisms of SARS-CoV-2 innate immune evasion including suppression of IFN-α/β production at the earliest stage of infection, mechanisms that exhaust natural killer cell-mediated cytotoxicity, overstimulation of NLRP3 inflammasome and induction of a cytokine storm. A comparison with SARS-CoV is made. Greater knowledge of these and other immune evasion tactics may provide us with improved possibilities for research into this novel deadly virus.
|
?:creator
|
|
?:doi
|
|
?:doi
|
|
?:journal
|
-
Reviews_in_medical_virology
|
?:license
|
|
?:pmid
|
|
?:pmid
|
|
?:publication_isRelatedTo_Disease
|
|
?:source
|
|
?:title
|
-
Innate immune evasion by SARS-CoV-2: Comparison with SARS-CoV.
|
?:type
|
|
?:year
|
|