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  • A nucleoside analog. Pyrazofurin potently inhibits orotidine 5\'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1208\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1208\' NCI Thesaurus)
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