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  • A murine IgM monoclonal antibody (MoAb) developed for the potential treatment of graft versus host disease (GvHD). Gavilimomab recognizes human CD147 antigen, weakly expressed on human leukocytes and up-regulated on activated lymphocytes. This MoAb is capable of neutralizing inflammatory reactions via a complement-dependent cytotoxic mechanism. However, gavilimomab does not offer an improvement over antithymocyte globulin in the treatment of acute steroid resistant GVHD. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2621\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2621\' NCI Thesaurus)
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