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  • Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5\' or 3\' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. [PMID:15300241, PMID:15788748]
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