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  • Germ Cell Tumors of the CNS constitute a unique class of rare tumors that affect mainly children and adolescents. Their histopathological and biological profile largely corresponds to that of homologous germ cell neoplasms arising in the gonads and in other extragonadal sites. Germ Cell Tumors of the CNS include: Germinoma, Embryonal Carcinoma, Yolk Sac Tumor (Endodermal Sinus Tumor), Choriocarcinoma, Mature Teratoma, Immature Teratoma, Teratoma with Malignant Transformation and Mixed Germ Cell Tumors. (Adapted from WHO.) Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C5461\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C5461\' NCI Thesaurus)
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