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  • TNFR2 is the receptor for the 171 amino acid 19 kD TNF-beta (a.k.a. lymphotoxin). TNF-beta is produced by activated lymphocytes and can be cytotoxic to many tumor and other cells. In neutrophils, endothelial cells and osteoclasts TNF-beta can lead to activation while in many other cell types it can lead to increased expression of MHC and adhesion molecules. (This definition may be outdated - see the DesignNote.)
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