C1520157_NCI_BioC | Knowledge4COVID-19

Property	Value
?:definition	Wnt glycoproteins play a role in diverse processes during embryonic patterning in metazoa through interaction with frizzled-type seven-transmembrane-domain receptors (Frz) to stabilize b-catenin. LDL-receptor-related protein 6 (LRP6), a Wnt co-receptor, is required for this interaction. Dikkopf (dkk) proteins are both positive and negative modulators of this signaling. (This definition may be outdated - see the DesignNote.)
?:hasCUIAnnotation	<https://research.tib.eu/covid-19/entity/C1520157>
?:hasGeneratedBy	<https://research.tib.eu/covid-19/SourceName/NCI_BioC>
?:type	<https://research.tib.eu/covid-19/vocab/AnnotationDefinition>

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