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Polymorphism detection microarrays designed to detect genetic variations in the genes 2D6 and 2C19 of the Cytochrome P450 pathway when used with a molecular assay analyzer. These microarrays can typically detect 29 known polymorphisms in the CYP2D6 gene, including gene duplication and deletion, resulting in the identification of 33 unique alleles; they can also permit the detection of two major polymorphisms in gene CYP2C19. These tests are used to characterize the patient phenotype, permitting a classification of the patient metabolic characteristics (e.g., poor, intermediate, extensive, or rapid metabolizers).
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