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  • A selective thiophene-derived tyrosine kinase inhibitor with potential antineoplastic activity. Tyrosine kinase inhibitor OSI-930 inhibits stem cell factor receptor (c-Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis.Both c-Kit and VEGFR2 are overexpressed in a variety of cancers. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C70981\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C70981\' NCI Thesaurus)
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