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  • Urticaria: o Many possible causes o Characterized by multiple transient wheals, usually with itching - Angioedema: o Similar to urticaria but involving the deeper dermal, submucosal and subcutaneous tissues o Sometimes associated with severe respiratory distress due to edema of the upper airways (e.g., laryngeal obstruction) o Edema results from dilatation and increased permeability of the capillaries - Urticaria and angioedema may appear separately or together o Similar process may occur at mucosal surfaces of the upper respiratory or gastrointestinal tract - Urticaria and/or angioedema are classified as: o IgE-dependent o Complement-mediated o Non-immunologic o Idiopathic
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