|
?:definition
|
-
Chronic inflammatory autoimmune disorder affecting many body systems with variable severity characterized by various autoantibodies o Antibodies to double-stranded DNA and Sm polypeptides o Antiphospholipid antibodies (including lupus anticoagulant, anticardiolipin antibodies, and those that cause false-positive tests for syphilis) o Complement activation leads to immune complex formation - Drugs may trigger systemic lupus erythematosus (SLE) symptoms de novo or exacerbate existing symptoms - Clinical presentations vary in severity and onset o Systemic symptoms: anorexia, weight loss, malaise, myalgia, arthralgias and fever o Cutaneous manifestations (e.g., macular \'butterfly\' erythema, discoid lesions, maculopapular lesions, erythema on sides of the palms, red or purple macular lesions on volar finger surfaces, alopecia, periungual erythema, mucus membrane lesions, purpura and photosensitivity o Polyarthritis o Nephritis - Proteinuria, diffuse membranoproliferative glomerulonephritis, abnormal urinalysis (hematuria, pyruia, urinary casts) or increased serum creatinine; hypertension and nephrotic syndrome can occur o Central nervous system manifestations - Headaches, epilepsy, psychoses, organic brain syndrome, personality changes, stroke and transient ischemic attacks d o Other manifestations/complications - Pericarditis, myocarditis, fibrinous (Libman-Sachs) endocarditis, and valve insufficiencies - Pleurisy with or without effusion - Anemia, leukopenia and thrombocytopenia due to hemolysis - Abdominal pain, nausea, vomiting and diarrhea - Sicca syndrome, nonspecific conjunctivitis, retinal vasculitis and optic neuritis
|
![[This page as RDF]](https://research.tib.eu/covid-19/static/rdf-icon.gif){kind=icon}