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  • A human heat-shock protein 90 (Hsp90) inhibitor, with potential antineoplastic activity. SNX-2112 selectively accumulates in tumors compared to normal tissues, and binds to the N-terminal adenosine triphosphate binding site of Hsp90, inhibiting its activity. This results in the proteasomal degradation of oncogenic client proteins, which prevents signaling through these client proteins, induces apoptosis and inhibits tumor cell proliferation. Hsp90 is a 90kDa molecular chaperone that plays a key role in the conformational maturation and stabilization of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation, proliferation, apoptosis, and survival; Hsp90 is overexpressed by certain types of tumor cells. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C91068\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C91068\' NCI Thesaurus)
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