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  • An I 131 radioiodinated synthetic analogue of the neurotransmitter norepinephrine, manufactured with a proprietary process, with radioisotopic and potential antineoplastic activities. cold contaminant-free iobenguane I 131 (MIBG) localizes to adrenergic tissue and may be used to image or eradicate tumor cells that accumulate and metabolize norepinephrine. This agent is manufactured using a technology that avoids the production of unwanted \'cold contaminants\' (i.e., carrier molecules), which may cause undesirable side effects and compete with MIBG for binding on target receptor sites. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82344\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C82344\' NCI Thesaurus)
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