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Image digitization systems designed to provide in-vivo bioluminescent and fluorescent images by imaging sources (i.e., fluorescent and bioluminescent reporters) between the blue and near infrared spectrum. These systems usually include fluorescent light sources that can provide reflected illumination and transillumination through a fiber-optic bundle and bundle switch, a charge coupled device (CCD) camera, emission and excitation filters, a scanning laser system intended only for alignment and surface topography, and imaging software for data acquisition and processing; and the use of a computer with a liquid-crystal display (LCD) monitor. Bioluminescence/fluorescence image digitization systems are used mainly to provide in-vivo images intended to detect cell activity, gene expression, and to assess disease progression in clinical research.
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