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  • Human TPM4 wild-type allele is located in the vicinity of 19p13.1 and is approximately 35 kb in length. This allele, which encodes tropomyosin alpha-4 chain protein, plays a role in both cytoskeletal modeling and smooth muscle cell contraction. A chromosomal translocation t(2;19)(p23;p13.1) of this gene and the ALK gene is associated with inflammatory myofibroblastic tumors.
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