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  • SMQ for generalized convulsive seizure (GCS) developed to address the occurrence of this form of seizure as an adverse event following immunization (AEFI). \'Seizure\' = abnormal paroxysmal discharge of cerebral neurons because of cortical hyperexcitability. Categories include: partial seizures (i.e., focal or localization related seizures); generalized. Generalized seizures are classified as: atonic; tonic; clonic; tonic-clonic; myoclonic; absence. Seizures are characterized by: sudden, involuntary muscular contractions; sensory disturbances; autonomic dysfunction; behavioral abnormalities; impairment or loss of consciousness. With GCS, patient becomes unconscious and has convulsions over whole body. Brighton Collaboration case definition of generalized convulsive seizure as AEFI describes the following levels of diagnostic certainty: Level 1 of diagnostic certainty - witnessed sudden loss of consciousness AND generalized, tonic, clonic, tonic-clonic, or atonic motor manifestations; Level 2 of diagnostic certainty - history of unconsciousness AND generalized, tonic, clonic, tonic-clonic, or atonic motor manifestations; Level 3 of diagnostic certainty - history of unconsciousness AND other generalized motor manifestations.
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