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  • Orthopedic cements, whose main components are polymethyl methacrylate (PMMA) and an antimicrobial agent (e.g., antibiotic), are designed to produce a mechanical interlocking effect upon hardening. These orthopedic cements consist of a powder (PMMA, prepolymerized PMMA, or methyl methacrylate co-polymer) including a pre-mixed antimicrobial agent and a liquid (methyl methacrylate monomer). Antimicrobial orthopedic cements are typically applied as runny liquids that set as a solid material in a time period that can be tailored to the surgeon\'s needs. These orthopedic cements eliminate the inconvenience of mixing an antimicrobial agent into the cement; the premixed powder helps to prevent inconsistency in cement-handling characteristics. They are used in orthopedic procedures to anchor metal or plastic prosthetic devices to bone or to treat spinal osteoporotic compression fractures while preventing microbial infection.
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