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  • A preparation of peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding a T cell chimeric antigen receptor (CAR) specific for mesothelin with potential immunostimulatory and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, the mesothelin-specific chimeric antigen receptor-engineered PBLs bind to tumor cells expressing mesothelin. This may stimulate the secretion of cytokines and result in cell lysis of mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers. Check for \'https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C101773\' active clinical trials using this agent. (\'http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C101773\' NCI Thesaurus)
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