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  • SMQ Noninfectious diarrhoea is intended to retrieve cases that may be drug related including antibiotic associated diarrhea not caused by Clostridium difficile or other infectious pathogens. Diarrhea defined as: increased frequency of bowel movements (>3 in 24 hours); and/or decreased stool consistency; and/or increased stool weight (>200g in 24 hours). Common side effect of many classes of medications, accounting for a high percentage of all adverse drug effects. Hundreds of drugs have been implicated in causing diarrhea. Most frequent are: antibiotics; laxatives; antihypertensives; lactulose or sorbitol containing products; antineoplastics; antiretroviral drugs; magnesium containing compounds; antiarrhythmics; non-steroidal anti-inflammatory drugs; colchicines; antacids and acid-reducing agents; prostaglandin analogs; and many supplements. Mechanisms of noninfectious diarrhea: non-inflammatory (e.g., osmotic or secretory diarrhea); inflammatory (e.g., cytotoxic effects of agents leading to intestinal mucositis)
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Metadata

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<http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2004/03/trix/rdfg-1/Graph>
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