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Molecular assay reagents intended to identify mutations in the catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1) gene, located at chromosome 3p21, which encodes for an adherens junction protein critical for the establishment and maintenance of epithelial layers and for signal transduction. Mutations at this locus have been identified in patients with several types of adenomatous and carcinomatous lesions, including colorectal cancer, hepatoblastoma, and pilomatricoma.
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