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  • Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine circulating antibodies against perinuclear antigens (i.e., antiperinuclear factor [APF)S. APFs appear to be sensitive but less specific in the determination of rheumatoid arthritis. Determination of APF may be used in combination with the determination of rheumatoid factor antibodies in the prognosis of early rheumatoid arthritis.
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